Survey 27 - OrthoCP - MeganeuronMCI Registration NumberFULL NAME (As in your Pancard)EmailPhone/MobileCityStateSpecialityBank DetailsAccount Holder NameA/c NumberIFSC CodeUpload Cancelled Cheque (Max Size - 2 MB)Choose File Pancard NumberUpload Pancard Details (Max Size - 2 MB)Choose File 1. Deficiency of Vitamin B & Vitamin D is associated with which of the following conditions Neuropathic Pain Osteoporosis Elevated homocysteine levels Muscles weakness & fatigue2. How does Vitamin B deficiency impair nerve health? By increasing blood sugar levels By impairing myelin sheath formation and maintenance Elevated homocysteine accumulation in the nerve cells By blocking dopamine production3. How does Vitamin B deficiency impair bone health? By reducing osteoblast activity and impairing bone formation. By increasing homocysteine levels, which weakens bone structure. By decreasing calcium absorption in the intestines.4. How does Vitamin D deficiency impair nerve health? Reduces synthesis of neurotrophic factors (e.g., NGF, BDNF) critical for neuron survival Blocks sodium-potassium pumps in axons Prevents GABA production in the spinal cord Causes demyelination via autoimmune destruction5. How does Vitamin D deficiency impair bone health? Reducing calcium absorption in the intestines Increasing osteoclast apoptosis Stimulating excess collagen production Blocking magnesium excretion6. How does Vitamin B & Vitamin D deficiency contribute to elevated homocysteine / Hyper- homocysteinemia in nerves? Vitamin B12/B9 deficiency impairs homocysteine remethylation, while Vitamin D deficiency exacerbates inflammation, further increasing homocysteine. Vitamin B deficiency leads to folate trapping, while Vitamin D deficiency directly inhibits cystathionine beta-synthase (CBS) in the transculturation pathway. Vitamin D deficiency upregulates inflammatory cytokines that impair homocysteine metabolism, while Vitamin B deficiency reduces S-adenosylmethionine (SAMe) production, worsening nerve toxicity7. How does supplementation of Vitamin B & Vitamin D benefit nerve & bone health in Diabetic Neuropathy patients? Lowering homocysteine levels and reducing oxidative nerve damage Increasing insulin secretion from pancreatic β-cells Blocking advanced glycation end-products (AGEs) formation Stimulating dopamine production in the CNS8. How does supplementation of Vitamin B & Vitamin D reduce elevated homocysteine / Hyper- homocysteinemia in Diabetic Neuropathy patients? Activating the remethylation pathway to convert homocysteine to methionine Inhibiting cystathionine beta-synthase (CBS) in the transsulfuration pathway Chelating excess homocysteine in the kidneys for excretion Blocking intestinal absorption of dietary homocysteine9. In which Orthopaedic conditions supplementation of Vitamin B & Vitamin D is ideally recommended? Nerve Entrapment disorders Osteoporosis/Osteopenia Osteoarthritis Spine disorders10. What is the recommended duration of therapy of Vitamin B & Vitamin D supplementation in Diabetic Neuropathy patients? 1–2 weeks 1–3 months 3–6 months Until deficiency persists I have read and agree to the Terms and Conditions .Submit Form